Collections / Aging-Related Cellular and Molecular Changes Reveal a Role for Bglap3+ Neurons in MEC Spatial Cognition

Aging-Related Cellular and Molecular Changes Reveal a Role for Bglap3+ Neurons in MEC Spatial Cognition

Aging-related cognitive decline, including impairments in spatial orientation and memory, has been linked to dysfunction within the hippocampus and medial entorhinal cortex (MEC). However, the cellular and molecular alterations underlying MEC aging remain poorly understood. Here we show that old mice exhibit a reduced proportion of grid cells and decreased spatial stability. Transcriptomic profiling of the MEC using 10x Genomics Visium technology reveals 1664 differentially expressed genes between young and old mice. Among these, Bglap3 is identified as a marker gene for a subpopulation of Layer III neurons that showed an age-associated reduction in cell number. Chemogenetic silencing of Bglap3+ neurons in young mice impairs spatial tuning of MEC neurons. Together, these findings elucidate cellular and molecular mechanisms contributing to age-related MEC dysfunction and suggest that the loss of Bglap3+ neurons may underlie spatial coding deficits in aging.

Datasets14
Size~842 MB
AssayVisium
Samplemouse · entorhinal cortex
KindOther
www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347650 ↗
Download the whole collection
Python · lamindb 
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse347650")
coll.ordered_artifacts.df()                 # the 14 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Member datasets · 14
Open in Vitessce
Visium
Mouse entorhinal cortex
GSM10058084
mouse entorhinal cortex 65 MB 2,940 obs silver H&E
TechnologyVisium
Organismmouse
Tissueentorhinal cortex
Size65 MB
Obs2,940
silver H&E Open in Vitessce
Visium
Mouse entorhinal cortex
GSM10058086
mouse entorhinal cortex 49 MB 2,920 obs silver H&E
TechnologyVisium
Organismmouse
Tissueentorhinal cortex
Size49 MB
Obs2,920
silver H&E
Open in Vitessce
Visium
Mouse entorhinal cortex
GSM10058088
mouse entorhinal cortex 58 MB 3,114 obs silver H&E
TechnologyVisium
Organismmouse
Tissueentorhinal cortex
Size58 MB
Obs3,114
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse entorhinal cortex
GSM10058085
mouse entorhinal cortex 50 MB 3,064 obs silver H&E
TechnologyVisium
Organismmouse
Tissueentorhinal cortex
Size50 MB
Obs3,064
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse entorhinal cortex
GSM10058082
mouse entorhinal cortex 68 MB 3,504 obs silver H&E
TechnologyVisium
Organismmouse
Tissueentorhinal cortex
Size68 MB
Obs3,504
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse entorhinal cortex
GSM10058090
mouse entorhinal cortex 59 MB 3,433 obs silver H&E
TechnologyVisium
Organismmouse
Tissueentorhinal cortex
Size59 MB
Obs3,433
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse entorhinal cortex
GSM10058087
mouse entorhinal cortex 53 MB 3,038 obs silver H&E
TechnologyVisium
Organismmouse
Tissueentorhinal cortex
Size53 MB
Obs3,038
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse entorhinal cortex
GSM10058083
mouse entorhinal cortex 64 MB 3,232 obs silver H&E
TechnologyVisium
Organismmouse
Tissueentorhinal cortex
Size64 MB
Obs3,232
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse entorhinal cortex
GSM10058095
mouse entorhinal cortex 64 MB 2,936 obs silver H&E
TechnologyVisium
Organismmouse
Tissueentorhinal cortex
Size64 MB
Obs2,936
silver H&E Open in Vitessce
Visium
Mouse entorhinal cortex
GSM10058096
mouse entorhinal cortex 63 MB 2,678 obs silver H&E
TechnologyVisium
Organismmouse
Tissueentorhinal cortex
Size63 MB
Obs2,678
silver H&E
Open in Vitessce
Visium
Mouse entorhinal cortex
GSM10058093
mouse entorhinal cortex 67 MB 3,363 obs silver H&E
TechnologyVisium
Organismmouse
Tissueentorhinal cortex
Size67 MB
Obs3,363
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse entorhinal cortex
GSM10058092
mouse entorhinal cortex 58 MB 3,037 obs silver H&E
TechnologyVisium
Organismmouse
Tissueentorhinal cortex
Size58 MB
Obs3,037
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse entorhinal cortex
GSM10058081
mouse entorhinal cortex 55 MB 3,447 obs silver H&E
TechnologyVisium
Organismmouse
Tissueentorhinal cortex
Size55 MB
Obs3,447
silver H&E Open in Vitessce
Visium
Mouse entorhinal cortex
GSM10058094
mouse entorhinal cortex 69 MB 3,139 obs silver H&E
TechnologyVisium
Organismmouse
Tissueentorhinal cortex
Size69 MB
Obs3,139
silver H&E

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