Collections / Spatial transcriptomics Reveals Impact of APOE4 Allele on α-Synuclein Aggregation and Cell-Cell Communication in Lewy Body Dementia

Spatial transcriptomics Reveals Impact of APOE4 Allele on α-Synuclein Aggregation and Cell-Cell Communication in Lewy Body Dementia

We performed spatial transcriptomics to understand a-synuclein pathology-specific molecular profiles and cell-cell communication in human Lewy Body Dementia (LBD) brains. We included APOE3/3 and APOE3/4 LBD brains to dissect APOE4 impact on a-synuclein pathologies. Our analysis showed the key dysregulated pathways around the pathology comparing LBD brains to control brains, which further exacerbated by APOE4.

Datasets10

Size~1.0 GB

AssayVisium

Samplehuman · temporal cortex

KindComparison

PMID:41588135 ↗

Download the whole collection

Python · lamindb

import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse293896")
coll.ordered_artifacts.df()                 # the 10 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}

Member datasets · 10

Visium

Human temporal cortex

GSM8893118

human temporal cortex Lewy body dementia 100 MB 10,187 obs bronze H&E

TechnologyVisium

Organismhuman

Tissuetemporal cortex

ConditionLewy body dementia

Size100 MB

Obs10,187

Magnificationother · 11.277 µm/px

bronze H&E

Visium

Human temporal cortex

GSM8893111

human temporal cortex 132 MB 13,235 obs bronze H&E

TechnologyVisium

Organismhuman

Tissuetemporal cortex

Size132 MB

Obs13,235

Magnificationother · 13.117 µm/px

bronze H&E

Visium

Human temporal cortex

GSM8893112

human temporal cortex 161 MB 12,985 obs bronze H&E

TechnologyVisium

Organismhuman

Tissuetemporal cortex

Size161 MB

Obs12,985

Magnificationother · 14.034 µm/px

bronze H&E

Visium

Human temporal cortex

GSM8893116

human temporal cortex Lewy body dementia 104 MB 11,447 obs bronze H&E

TechnologyVisium

Organismhuman

Tissuetemporal cortex

ConditionLewy body dementia

Size104 MB

Obs11,447

Magnificationother · 12.881 µm/px

bronze H&E

Visium

Human temporal cortex

GSM8893117

human temporal cortex Lewy body dementia 58 MB 7,611 obs bronze H&E

TechnologyVisium

Organismhuman

Tissuetemporal cortex

ConditionLewy body dementia

Size58 MB

Obs7,611

Magnificationother · 13.113 µm/px

bronze H&E

Visium

Human temporal cortex

GSM8893114

human temporal cortex 116 MB 11,931 obs bronze H&E

TechnologyVisium

Organismhuman

Tissuetemporal cortex

Size116 MB

Obs11,931

Magnificationother · 12.655 µm/px

bronze H&E

Visium

Human temporal cortex

GSM8893119

human temporal cortex Lewy body dementia 94 MB 11,002 obs bronze H&E

TechnologyVisium

Organismhuman

Tissuetemporal cortex

ConditionLewy body dementia

Size94 MB

Obs11,002

Magnificationother · 8.058 µm/px

bronze H&E

Visium

Human temporal cortex

GSM8893115

human temporal cortex Lewy body dementia 81 MB 12,011 obs bronze H&E

TechnologyVisium

Organismhuman

Tissuetemporal cortex

ConditionLewy body dementia

Size81 MB

Obs12,011

Magnificationother · 13.133 µm/px

bronze H&E

Visium

Human temporal cortex

GSM8893120

human temporal cortex Lewy body dementia 75 MB 13,770 obs bronze H&E

TechnologyVisium

Organismhuman

Tissuetemporal cortex

ConditionLewy body dementia

Size75 MB

Obs13,770

bronze H&E

Visium

Human temporal cortex

GSM8893113

human temporal cortex 109 MB 13,079 obs bronze H&E

TechnologyVisium

Organismhuman

Tissuetemporal cortex

Size109 MB

Obs13,079

Magnificationother · 11.975 µm/px

bronze H&E

Cite this collection

No linked publication found — please cite the data source.