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spatial transcriptomics

Human breast

SPA150

silver Interactive viewer H&E invasive ductal breast carcinoma Provisional
Human breast preview
print(sdata)
SpatialData object
├── Images
│     └── 'SPA150_full_image': DataTree[cyx] (3, 7419, 6966), (3, 3709, 3483), (3, 1854, 1741), (3, 927, 870)
├── Shapes
│     └── 'SPA150_spots': GeoDataFrame shape: (332, 2) (2D shapes)
└── Tables
      └── 'table': AnnData (332, 15388)
with coordinate systems:
    ▸ 'global', with elements:
        SPA150_full_image (Images), SPA150_spots (Shapes)
Load in Python
import lamindb as ln

db = ln.DB("scverse/spatialdata-db")
artifact = db.Artifact.get("3E0Wrfsge3mlI3YP")   # latest version

sdata = artifact.load()   # cache, then load into memory
group = artifact.open()   # stream without downloading
path  = artifact.cache()  # sync into the local cache, returns the path
Load from the CLI
# one-shot: cache the dataset and print its local path
lamin load https://lamin.ai/scverse/spatialdata-db/artifact/3E0Wrfsge3mlI3YP

# or connect once, then load by uid
lamin connect scverse/spatialdata-db
lamin load artifact --uid 3E0Wrfsge3mlI3YP
Load with the Python client
# pip install git+https://github.com/theislab/spatialdata-db-client
from sddb import Catalog

ds = Catalog().cohort(uids=["3E0Wrfsge3mlI3YP0000"])[0]
ds.elements()                 # inspect without downloading
sdata = ds.load(lazy=False)   # copy to the local cache and open

Docs: finding & loading data →

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Metadata

Technology
spatial transcriptomics
Organism
human
Tissue
breast
Condition
invasive ductal breast carcinoma
Modality
RNA
Observations
332
Tier
silver
Chemistry
ST 1k
Resolution
6,966 × 7,419 px
mpp
0.946 µm/px
Size
90 MB
Sample ID
SPA150
License
CC BY-NC-SA 4.0 NonCommercial
Published
Sep 16, 2021

Cite this dataset

doi.org/10.1038/s41467-021-26271-2 ↗
BibTeX
@article{Andersson_2021,
  title = {Spatial deconvolution of HER2-positive breast cancer delineates tumor-associated cell type interactions},
  volume = {12},
  ISSN = {2041-1723},
  url = {http://dx.doi.org/10.1038/s41467-021-26271-2},
  DOI = {10.1038/s41467-021-26271-2},
  number = {1},
  journal = {Nature Communications},
  publisher = {Springer Science and Business Media LLC},
  author = {Andersson, Alma and Larsson, Ludvig and Stenbeck, Linnea and Salmén, Fredrik and Ehinger, Anna and Wu, Sunny Z. and Al-Eryani, Ghamdan and Roden, Daniel and Swarbrick, Alex and Borg, Åke and Frisén, Jonas and Engblom, Camilla and Lundeberg, Joakim},
  year = {2021},
  month = Oct
}

Source: NCBI GEO ↗ · License: CC BY-NC-SA 4.0 ↗ · Reprocessed to SpatialData by SpatialData-DB