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10x Xenium

Mouse brain

GSM8647395

silver ✓ Verified publication
Mouse brain preview
print(sdata)
SpatialData object
├── Images
│     ├── 'morphology_focus': DataTree[cyx] (1, 34133, 42664), (1, 17066, 21332), (1, 8533, 10666), (1, 4266, 5333), (1, 2133, 2666)
│     └── 'morphology_mip': DataTree[cyx] (1, 34133, 42664), (1, 17066, 21332), (1, 8533, 10666), (1, 4266, 5333), (1, 2133, 2666)
├── Labels
│     ├── 'cell_labels': DataTree[yx] (34133, 42664), (17066, 21332), (8533, 10666), (4266, 5333), (2133, 2666)
│     └── 'nucleus_labels': DataTree[yx] (34133, 42664), (17066, 21332), (8533, 10666), (4266, 5333), (2133, 2666)
├── Points
│     └── 'transcripts': DataFrame with shape: (62354539, 10) (3D points)
├── Shapes
│     ├── 'cell_boundaries': GeoDataFrame shape: (125103, 1) (2D shapes)
│     ├── 'cell_circles': GeoDataFrame shape: (125103, 2) (2D shapes)
│     └── 'nucleus_boundaries': GeoDataFrame shape: (125103, 1) (2D shapes)
└── Tables
      └── 'table': AnnData (125103, 347)
with coordinate systems:
    ▸ 'global', with elements:
        morphology_focus (Images), morphology_mip (Images), cell_labels (Labels), nucleus_labels (Labels), transcripts (Points), cell_boundaries (Shapes), cell_circles (Shapes), nucleus_boundaries (Shapes)
Load in Python
import lamindb as ln

db = ln.DB("scverse/spatialdata-db")
artifact = db.Artifact.get("Um0SuU7W2YJBJpRX")   # latest version

sdata = artifact.load()   # cache, then load into memory
group = artifact.open()   # stream without downloading
path  = artifact.cache()  # sync into the local cache, returns the path
Load from the CLI
# one-shot: cache the dataset and print its local path
lamin load https://lamin.ai/scverse/spatialdata-db/artifact/Um0SuU7W2YJBJpRX

# or connect once, then load by uid
lamin connect scverse/spatialdata-db
lamin load artifact --uid Um0SuU7W2YJBJpRX
Load with the Python client
# pip install git+https://github.com/theislab/spatialdata-db-client
from sddb import Catalog

ds = Catalog().cohort(uids=["Um0SuU7W2YJBJpRX0000"])[0]
ds.elements()                 # inspect without downloading
sdata = ds.load(lazy=False)   # copy to the local cache and open

Docs: finding & loading data →

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Metadata

Technology
10x Xenium
Organism
mouse
Tissue
brain
Modality
RNA
Observations
125,103
Transcripts
62,354,539
Tier
silver
Chemistry
Xenium v1
Size
5.8 GB
Sample ID
GSM8647395
License
NCBI GEO policy
Published
Dec 20, 2024

Cite this dataset

doi.org/10.1016/j.celrep.2024.115194 ↗
BibTeX
@article{Willis_2025,
  title = {Single cell approaches define neural stem cell niches and identify microglial ligands that can enhance precursor-mediated oligodendrogenesis},
  volume = {44},
  ISSN = {2211-1247},
  url = {http://dx.doi.org/10.1016/j.celrep.2024.115194},
  DOI = {10.1016/j.celrep.2024.115194},
  number = {1},
  journal = {Cell Reports},
  publisher = {Elsevier BV},
  author = {Willis, Ashleigh and Jeong, Danielle and Liu, Yunlong and Lithopoulos, Marissa A. and Yuzwa, Scott A. and Frankland, Paul W. and Kaplan, David R. and Miller, Freda D.},
  year = {2025},
  month = Jan,
  pages = {115194}
}

Source: NCBI GEO ↗ · License: NCBI GEO policy ↗ · Reprocessed to SpatialData by SpatialData-DB