Collections / Prenatal DBP Exposure Dysregulate Fetal-Placenta Spatial Transcriptomic Profiles

Prenatal DBP Exposure Dysregulate Fetal-Placenta Spatial Transcriptomic Profiles

Dibutyl phthalate (DBP), a phthalate congener, is widely utilized in consumer products and medication coatings. Women of reproductive age have a significant burden of DBP exposure. Prenatal DBP exposure is associated with adverse pregnancy/fetal outcomes in the offspring. However, the role of fetal sex and the general mechanisms underlying DBP exposure-associated adverse pregnancy outcomes are unclear. This study characterized fetal sex-specific spatial transcriptomic responses in gestational day 18.5 mouse placentas from fetuses with and without prenatal DBP exposure.

Datasets12
Size~450 MB
AssayVisium
Samplemouse · placenta
KindComparison
PMID:42523464 ↗
Download the whole collection
Python · lamindb 
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse333401")
coll.ordered_artifacts.df()                 # the 12 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Member datasets · 12
Open in Vitessce
Visium
Mouse placenta
GSM9762121
mouse placenta 45 MB 1,961 obs bronze H&E
TechnologyVisium
Organismmouse
Tissueplacenta
Size45 MB
Obs1,961
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762114
mouse placenta 24 MB 1,372 obs bronze H&E
TechnologyVisium
Organismmouse
Tissueplacenta
Size24 MB
Obs1,372
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762117
mouse placenta 31 MB 1,237 obs bronze H&E
TechnologyVisium
Organismmouse
Tissueplacenta
Size31 MB
Obs1,237
Magnificationother · 3.362 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762125
mouse placenta 50 MB 2,411 obs bronze H&E
TechnologyVisium
Organismmouse
Tissueplacenta
Size50 MB
Obs2,411
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762119
mouse placenta 28 MB 1,861 obs bronze H&E
TechnologyVisium
Organismmouse
Tissueplacenta
Size28 MB
Obs1,861
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762115
mouse placenta 26 MB 1,624 obs bronze H&E
TechnologyVisium
Organismmouse
Tissueplacenta
Size26 MB
Obs1,624
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762118
mouse placenta 24 MB 859 obs bronze H&E
TechnologyVisium
Organismmouse
Tissueplacenta
Size24 MB
Obs859
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762123
mouse placenta 45 MB 1,598 obs bronze H&E
TechnologyVisium
Organismmouse
Tissueplacenta
Size45 MB
Obs1,598
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762124
mouse placenta 39 MB 1,587 obs bronze H&E
TechnologyVisium
Organismmouse
Tissueplacenta
Size39 MB
Obs1,587
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762120
mouse placenta 55 MB 2,080 obs bronze H&E
TechnologyVisium
Organismmouse
Tissueplacenta
Size55 MB
Obs2,080
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762116
mouse placenta 51 MB 2,087 obs bronze H&E
TechnologyVisium
Organismmouse
Tissueplacenta
Size51 MB
Obs2,087
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM9762113
mouse placenta 33 MB 2,281 obs bronze H&E
TechnologyVisium
Organismmouse
Tissueplacenta
Size33 MB
Obs2,281
bronze H&E Open in Vitessce

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