Collections / Spatial transcriptomic analysis of human iPSC-derived hemanoids at day 16 and day 28

Spatial transcriptomic analysis of human iPSC-derived hemanoids at day 16 and day 28

Human induced pluripotent stem cell (iPSC)-derived hemanoids provide a three-dimensional model to study early hematopoietic development in vitro. To characterize the spatial organization and transcriptional dynamics of this system, we performed spatial transcriptomic profiling of FFPE hemanoids at day 16 and day 28 of differentiation using the 10x Genomics Visium Spatial Gene Expression platform (Visium v1 chemistry). This dataset captures the identification and spatial distribution of hematopoietic cells within the three-germ-layer-derived hemanoid environment.

Datasets2
Size~28 MB
AssayVisium
Samplehuman · hematopoietic system
KindTime course
www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324601 ↗
Download the whole collection
Python · lamindb 
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse324601")
coll.ordered_artifacts.df()                 # the 2 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Member datasets · 2
Open in Vitessce
Visium
Human hematopoietic system
GSM9580061
human hematopoietic system 16 MB 1,024 obs silver H&E
TechnologyVisium
Organismhuman
Tissuehematopoietic system
Size16 MB
Obs1,024
silver H&E Open in Vitessce
Open in Vitessce
Visium
Human hematopoietic system
GSM9580062
human hematopoietic system 12 MB 1,354 obs silver H&E
TechnologyVisium
Organismhuman
Tissuehematopoietic system
Size12 MB
Obs1,354
silver H&E Open in Vitessce

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