Visium Mouse lung
GSM9191676
mouse lung lung adenocarcinoma 67 MB 3,511 obs bronze H&E
TechnologyVisium
Organismmouse
Tissuelung
Conditionlung adenocarcinoma
Obs3,511
Magnificationother · 5.974 µm/px
bronze H&E
Collections / Genetic deletion of Usp22 in KRASG12D-p53-null driven mouse lung cancer [Visium]
Genetic deletion of Usp22 in KRASG12D-p53-null driven mouse lung cancer [Visium]
Ubiquitin-specific peptidase 22 (USP22), a deubiquitinase and component of the “Death-By-Cancer” 11-gene signature, is overexpressed in multiple cancers and linked to recurrence, therapy resistance, and poor prognosis. While its role in tumor immune evasion is emerging, the function of USP22 in KRAS-driven lung cancer and antitumor immunity remains largely unknown. Given that oncogenic KRAS promotes an immunosuppressive tumor microenvironment (TME) and resistance to immunotherapy, this study investigates USP22's role in KRAS-driven lung cancer and its potential impacts on carcinogenesis and anticancer immunity. For this purpose, Usp22 knockout (Usp22-KO) mouse model was developed in the KRASG12D; p53−/− (KP) background, cancers were induced, and spatial transcriptomics was applied to define the difference in TME of mouse KP verse USP22-KO-KP (KPU-) lung cancer.
Datasets2
Size~143 MB
AssayVisium
Samplemouse · lung
KindComparison
Download the whole collection
Python · lamindb
import lamindb as ln
import spatialdata as sd
coll = ln.Collection.get(key="geo-gse306019")
coll.ordered_artifacts.df() # the 2 members, ordered
# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]
# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}Member datasets · 2
Visium 
Visium Mouse lung
GSM9191675
mouse lung lung adenocarcinoma 76 MB 3,405 obs bronze H&E
TechnologyVisium
Organismmouse
Tissuelung
Conditionlung adenocarcinoma
Obs3,405
bronze H&E
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