Collections / Spatial transcriptomics of the human first trimester decidua

Spatial transcriptomics of the human first trimester decidua

Understanding how extravillous trophoblasts (EVTs) reshape the maternal uterine environment (decidua basalis) is critical for deciphering early human placental development. To study the impact of EVT invasion on the distribution of immune cells and the restructuring of the decidual tissue, we performed spatial transcriptomic profiling using the Visium platform (10x Genomics) on first trimester decidua.

Datasets4
Size~133 MB
AssayVisium
Samplehuman · multiple
KindComparison
PMID:42248577 ↗
Python · lamindb
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse301306")
coll.ordered_artifacts.df()                 # the 4 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Open in Vitessce
Visium
Human decidua basalis
GSM9080378
human decidua basalis 38 MB 1,800 obs bronze H&E
TechnologyVisium
Organismhuman
Tissuedecidua basalis
Size38 MB
Obs1,800
Magnificationother · 3.960 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Human decidua parietalis
GSM9080379
human decidua parietalis 42 MB 1,973 obs bronze H&E
TechnologyVisium
Organismhuman
Tissuedecidua parietalis
Size42 MB
Obs1,973
Magnificationother · 3.955 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Human decidua parietalis
GSM9080377
human decidua parietalis 33 MB 1,482 obs bronze H&E
TechnologyVisium
Organismhuman
Tissuedecidua parietalis
Size33 MB
Obs1,482
Magnificationother · 3.955 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Human decidua basalis
GSM9080376
human decidua basalis 21 MB 871 obs bronze H&E
TechnologyVisium
Organismhuman
Tissuedecidua basalis
Size21 MB
Obs871
Magnificationother · 3.960 µm/px
bronze H&E Open in Vitessce

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