Visium Mouse heart
GSM8998316
mouse heart myocarditis 75 MB 2,503 obs silver H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissueheart
Conditionmyocarditis
Obs2,503
silver H&E NCBI GEO policy
Collections / IL-17A Neutralization Prevents Immune Checkpoint Inhibitor-Associated Myocarditis and Synergistically Enhances Immune Checkpoint Blockade Therapy
IL-17A Neutralization Prevents Immune Checkpoint Inhibitor-Associated Myocarditis and Synergistically Enhances Immune Checkpoint Blockade Therapy
Immune checkpoint inhibitor (ICI)-associated myocarditis is a severe and often fatal immune-related adverse event observed in cancer immunotherapy. To investigate its pathogenesis and prevention, we performed spatial transcriptomics on cardiac tissue from mice treated with dual ICIs (anti–PD-1 and anti–CTLA-4) with or without IL-17A neutralizing antibody. Our analysis revealed immune-mediated fibrotic remodeling and distinct spatial immune cell distributions, providing insights into how IL-17A blockade mitigates cardiac toxicity without compromising immune activation.
Datasets2
Size~157 MB
AssayVisium
Samplemouse · heart
KindOther
Download the whole collection
Python · lamindb
import lamindb as ln
import spatialdata as sd
coll = ln.Collection.get(key="geo-gse297745")
coll.ordered_artifacts.df() # the 2 members, ordered
# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]
# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}Member datasets · 2
Visium 
Visium Mouse heart
GSM8998317
mouse heart myocarditis 81 MB 3,052 obs silver H&E NCBI GEO policy
TechnologyVisium
Organismmouse
Tissueheart
Conditionmyocarditis
Obs3,052
silver H&E NCBI GEO policy
Cite this collection
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