Collections / Multi-omics analysis identifies erythroid cells as the major population in mouse placentas expressing the MHC class II antigen presentation, chemokine, and antibacterial immune response genes [Spatial Transcriptomics]

Multi-omics analysis identifies erythroid cells as the major population in mouse placentas expressing the MHC class II antigen presentation, chemokine, and antibacterial immune response genes [Spatial Transcriptomics]

Pregnancy is one of the most important processes for mammals, which is deeply controlled by the immune system. We performed spatial transcriptomics to profile mouse placentas from semi-allogeneic and syngeneic pregnancies at E12.5 to elucidate differences between these types of pregnancies. Our analysis showed that erythroid cells were the major immunoregulatory population in both types of pregnancies.

Datasets3
Size~93 MB
AssayVisium
Samplemouse · placenta
KindOther
PMID:41058694 ↗
Python · lamindb
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse289170")
coll.ordered_artifacts.df()                 # the 3 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Open in Vitessce
Visium
Mouse placenta
GSM8785671
mouse placenta 34 MB 2,898 obs silver H&E
TechnologyVisium
Organismmouse
Tissueplacenta
Size34 MB
Obs2,898
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM8785670
mouse placenta 31 MB 3,569 obs silver H&E
TechnologyVisium
Organismmouse
Tissueplacenta
Size31 MB
Obs3,569
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse placenta
GSM8785666
mouse placenta 29 MB 2,599 obs silver H&E
TechnologyVisium
Organismmouse
Tissueplacenta
Size29 MB
Obs2,599
silver H&E Open in Vitessce

Cite this collection

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