Collections / Spatial transcriptomics for high-grade serous ovarian carcinoma who were treated with Olaparib maintenance therapy

Spatial transcriptomics for high-grade serous ovarian carcinoma who were treated with Olaparib maintenance therapy

Ovarian cancer is one of the leading causes of death among females worldwide. Recently, PARP inhibitors have become widely used for maintenance therapy in ovarian cancer, leading to improvements in patient prognosis. However, resistance to PARP inhibitors is observed in some cases, presenting a clinical challenge. In this study, we investigated the mechanisms of Olaparib resistance using spatial transcriptomics.

Datasets8
Size~362 MB
AssayVisium
Samplehuman · ovary
KindComparison
PMID:41219363 ↗
Download the whole collection
Python · lamindb 
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse288483")
coll.ordered_artifacts.df()                 # the 8 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Member datasets · 8
Open in Vitessce
Visium
Human ovary
GSM8768682
human ovary ovarian serous adenocarcinoma 36 MB 1,393 obs bronze H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size36 MB
Obs1,393
Magnificationother · 3.681 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Human ovary
GSM8768684
human ovary ovarian serous adenocarcinoma 50 MB 2,026 obs bronze H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size50 MB
Obs2,026
Magnificationother · 4.060 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Human ovary
GSM8768686
human ovary ovarian serous adenocarcinoma 65 MB 3,284 obs bronze H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size65 MB
Obs3,284
Magnificationother · 4.059 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Human ovary
GSM8768680
human ovary ovarian serous adenocarcinoma 30 MB 1,131 obs bronze H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size30 MB
Obs1,131
Magnificationother · 3.682 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Human ovary
GSM8768683
human ovary ovarian serous adenocarcinoma 46 MB 1,833 obs bronze H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size46 MB
Obs1,833
Magnificationother · 4.060 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Human ovary
GSM8768681
human ovary ovarian serous adenocarcinoma 47 MB 2,002 obs bronze H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size47 MB
Obs2,002
Magnificationother · 3.680 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Human ovary
GSM8768679
human ovary ovarian serous adenocarcinoma 35 MB 1,534 obs bronze H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size35 MB
Obs1,534
Magnificationother · 3.678 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Human ovary
GSM8768685
human ovary ovarian serous adenocarcinoma 53 MB 2,119 obs bronze H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size53 MB
Obs2,119
bronze H&E Open in Vitessce

Cite this collection

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