Collections / Spatial Gene Expression of Human Coronary Arteries Revealed the Molecular Features of Diffuse Intimal Thickening in Explanted Hearts

Spatial Gene Expression of Human Coronary Arteries Revealed the Molecular Features of Diffuse Intimal Thickening in Explanted Hearts

Diffuse intimal thickening (DIT) is a preclinical stage of atherogenesis in humans that does not exist in commonly used mouse models of atherosclerosis. Vascular smooth muscle cells (SMCs) are the predominant cell type that occupies the intimal and medial layers of human coronary arteries. The intimal layer of DIT is particularly prone to developing atherosclerosis later in life. Differences in the molecular features between the intimal and medial layers of DIT regions may represent the earliest changes that promote atherogenesis in humans, and can be studied by spatial molecular phenotyping.

Datasets6
Size~156 MB
AssayVisium
Samplehuman · coronary artery
KindOther
PMID:40076574 ↗
Download the whole collection
Python · lamindb 
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse283269")
coll.ordered_artifacts.df()                 # the 6 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Member datasets · 6
Open in Vitessce
Visium
Human coronary artery
GSM8658911
human coronary artery atherosclerosis 24 MB 799 obs silver H&E
TechnologyVisium
Organismhuman
Tissuecoronary artery
Conditionatherosclerosis
Size24 MB
Obs799
silver H&E Open in Vitessce
Open in Vitessce
Visium
Human coronary artery
GSM8658913
human coronary artery atherosclerosis 32 MB 1,741 obs silver H&E
TechnologyVisium
Organismhuman
Tissuecoronary artery
Conditionatherosclerosis
Size32 MB
Obs1,741
silver H&E Open in Vitessce
Open in Vitessce
Visium
Human coronary artery
GSM8658914
human coronary artery atherosclerosis 23 MB 999 obs silver H&E
TechnologyVisium
Organismhuman
Tissuecoronary artery
Conditionatherosclerosis
Size23 MB
Obs999
silver H&E Open in Vitessce
Open in Vitessce
Visium
Human coronary artery
GSM8658916
human coronary artery atherosclerosis 31 MB 952 obs silver H&E
TechnologyVisium
Organismhuman
Tissuecoronary artery
Conditionatherosclerosis
Size31 MB
Obs952
silver H&E Open in Vitessce
Open in Vitessce
Visium
Human coronary artery
GSM8658912
human coronary artery atherosclerosis 21 MB 732 obs silver H&E
TechnologyVisium
Organismhuman
Tissuecoronary artery
Conditionatherosclerosis
Size21 MB
Obs732
silver H&E Open in Vitessce
Open in Vitessce
Visium
Human coronary artery
GSM8658915
human coronary artery atherosclerosis 24 MB 1,359 obs silver H&E
TechnologyVisium
Organismhuman
Tissuecoronary artery
Conditionatherosclerosis
Size24 MB
Obs1,359
silver H&E Open in Vitessce

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