Visium Mouse brain
GSM8604635
mouse brain tic disorder 99 MB 3,294 obs silver H&E
TechnologyVisium
Organismmouse
Tissuebrain
Conditiontic disorder
Obs3,294
silver H&E
Collections / Spatial component of: CELSR3 deficiency leads to tic-related behaviors and dopaminergic alterations in the striatum
Spatial component of: CELSR3 deficiency leads to tic-related behaviors and dopaminergic alterations in the striatum
The gene CELSR3 (cadherin EGF LAG seven‐pass-G‐type receptor 3) has been recently recognized as a high-confidence risk factor for tic disorders (TD). Celsr3 mutant mice displayed tic-like grooming stereotypies and jerks, as well as sensorimotor gating deficits, which were opposed by TD therapies. Spatial transcriptomic analyses revealed that Celsr3 mutants featured abnormalities of the extracellular matrix in the striatum. Notably, there are alterations in collagen and extracellular organization.
Datasets4
Size~412 MB
AssayVisium
Samplemouse · brain
KindComparison
Download the whole collection
Python · lamindb
import lamindb as ln
import spatialdata as sd
coll = ln.Collection.get(key="geo-gse280709")
coll.ordered_artifacts.df() # the 4 members, ordered
# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]
# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}Member datasets · 4
Visium 
Visium Mouse brain
GSM8604632
mouse brain 107 MB 3,055 obs silver H&E
TechnologyVisium
Organismmouse
Tissuebrain
Obs3,055
silver H&E
Visium Mouse brain
GSM8604633
mouse brain tic disorder 112 MB 3,445 obs silver H&E
TechnologyVisium
Organismmouse
Tissuebrain
Conditiontic disorder
Obs3,445
silver H&E
Visium Mouse brain
GSM8604634
mouse brain 94 MB 2,808 obs silver H&E
TechnologyVisium
Organismmouse
Tissuebrain
Obs2,808
silver H&E
Cite this collection
No linked publication found — please cite the data source.