Collections / Spatially-restricted and ontogenically-distinct hepatic macrophages are required for tissue repair.

Spatially-restricted and ontogenically-distinct hepatic macrophages are required for tissue repair.

Analysis of single cell RNA-seq, CITE-seq data and bulk RNA-seq data on cells isolated from the livers of mice following PBS and APAP (paracetamol/acetaminophen) administration. Spatial Transcriptomics analysis was performed using 10x Visium platform on mouse livers 48hrs post PBS or APAP administration. We also analysed single cell RNA-seq data on CD64+F4/80+ macrophages isolated from the livers of Trem2 fl/fl mice and CD64CRE Trem2 fl/fl mice.

Datasets3
Size~55 MB
AssayVisium
Samplemouse · liver
KindComparison
PMID:39862865 ↗
Python · lamindb
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse280515")
coll.ordered_artifacts.df()                 # the 3 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Open in Vitessce
Visium
Mouse liver
GSM8599604
mouse liver drug-induced liver injury 24 MB 2,178 obs silver H&E
TechnologyVisium
Organismmouse
Tissueliver
Conditiondrug-induced liver injury
Size24 MB
Obs2,178
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse liver
GSM8599603
mouse liver drug-induced liver injury 16 MB 1,272 obs silver H&E
TechnologyVisium
Organismmouse
Tissueliver
Conditiondrug-induced liver injury
Size16 MB
Obs1,272
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse liver
GSM8599602
mouse liver 15 MB 1,790 obs silver H&E
TechnologyVisium
Organismmouse
Tissueliver
Size15 MB
Obs1,790
silver H&E Open in Vitessce

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