Collections / Spatial transcriptomics for platinum-resistant high-grade serous ovarian carcinoma

Spatial transcriptomics for platinum-resistant high-grade serous ovarian carcinoma

Ovarian cancer is one of the leading causes of death in females in the world. High-grade serous ovarian carcinoma (HGSOC) is the most common histological subtype, and the platinum-resistance is a clinical challenge. Moreover, JAK1-related inflammation may contribute to the platinum-resistance. This study investigated the spatial gene expression profiles of JAK1-high and -low expressed HGSOC.

Datasets3
Size~202 MB
AssayVisium
Samplehuman · ovary
KindReplicates
PMID:40883550 ↗
Download the whole collection
Python · lamindb 
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse274657")
coll.ordered_artifacts.df()                 # the 3 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Member datasets · 3
Open in Vitessce
Visium
Human ovary
GSM8454235
human ovary ovarian serous adenocarcinoma 103 MB 4,116 obs bronze H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size103 MB
Obs4,116
Magnificationother · 3.753 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Human ovary
GSM8454234
human ovary ovarian serous adenocarcinoma 54 MB 1,534 obs bronze H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size54 MB
Obs1,534
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Human ovary
GSM8454237
human ovary ovarian serous adenocarcinoma 45 MB 4,992 obs bronze H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size45 MB
Obs4,992
bronze H&E Open in Vitessce

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