Collections / Consequences of the perivascular niche remodeling for tumoricidal T-cell trafficking into metastasis of ovarian cancer [Spatial Transciptomics]

Consequences of the perivascular niche remodeling for tumoricidal T-cell trafficking into metastasis of ovarian cancer [Spatial Transciptomics]

We investigated the mechanisms by which inflammatory responses generated by tumor-specific T cells delivered to ovarian tumor-bearing mice alone or after oncolytic vaccinia virus-driven immunogenic cancer cell death affect antitumor efficacy using spatial transcriptomics.

Datasets4
Size~184 MB
AssayVisium
Samplemouse · ovary
KindComparison
PMID:39372930 ↗
Python · lamindb
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse274509")
coll.ordered_artifacts.df()                 # the 4 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Open in Vitessce
Visium
Mouse ovary
GSM8450581
mouse ovary ovarian cancer 38 MB 2,329 obs bronze H&E
TechnologyVisium
Organismmouse
Tissueovary
Conditionovarian cancer
Size38 MB
Obs2,329
Magnificationother · 3.366 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse ovary
GSM8450580
mouse ovary ovarian cancer 36 MB 1,676 obs bronze H&E
TechnologyVisium
Organismmouse
Tissueovary
Conditionovarian cancer
Size36 MB
Obs1,676
Magnificationother · 3.323 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse ovary
GSM8450578
mouse ovary ovarian cancer 64 MB 2,823 obs bronze H&E
TechnologyVisium
Organismmouse
Tissueovary
Conditionovarian cancer
Size64 MB
Obs2,823
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse ovary
GSM8450579
mouse ovary ovarian cancer 45 MB 2,312 obs bronze H&E
TechnologyVisium
Organismmouse
Tissueovary
Conditionovarian cancer
Size45 MB
Obs2,312
bronze H&E Open in Vitessce

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