Collections / Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma [Spatial Transcriptomics]

Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma [Spatial Transcriptomics]

To functionally assess the role of pericytes in glioma development and progression, we study the effects of pericyte depletion in orthotopic and transgenic mouse models of high-grade glioma using single-cell and spatial transcriptomics. We present evidence that pericytes mitigate glioma development by orchestrating a tumor-suppressive microenvironment, challenging the concept of pericytes as merely pro-oncogenic cells, and underscoring the importance of pericyte preservation in future GBM therapies.

Datasets8
Size~318 MB
AssayVisium
Samplemouse · brain
KindComparison
PMID:41339360 ↗
Download the whole collection
Python · lamindb 
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse272236")
coll.ordered_artifacts.df()                 # the 8 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Member datasets · 8
Open in Vitessce
Visium
Mouse brain
GSM8396159
mouse brain glioma 24 MB 1,462 obs bronze H&E
TechnologyVisium
Organismmouse
Tissuebrain
Conditionglioma
Size24 MB
Obs1,462
Magnificationother · 3.577 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse brain
GSM8396166
mouse brain glioma 54 MB 2,887 obs bronze H&E
TechnologyVisium
Organismmouse
Tissuebrain
Conditionglioma
Size54 MB
Obs2,887
Magnificationother · 3.583 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse brain
GSM8396161
mouse brain glioma 53 MB 2,723 obs bronze H&E
TechnologyVisium
Organismmouse
Tissuebrain
Conditionglioma
Size53 MB
Obs2,723
Magnificationother · 3.581 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse brain
GSM8396160
mouse brain glioma 24 MB 1,398 obs bronze H&E
TechnologyVisium
Organismmouse
Tissuebrain
Conditionglioma
Size24 MB
Obs1,398
Magnificationother · 3.595 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse brain
GSM8396163
mouse brain glioma 34 MB 2,301 obs bronze H&E
TechnologyVisium
Organismmouse
Tissuebrain
Conditionglioma
Size34 MB
Obs2,301
Magnificationother · 3.581 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse brain
GSM8396162
mouse brain glioma 35 MB 1,921 obs bronze H&E
TechnologyVisium
Organismmouse
Tissuebrain
Conditionglioma
Size35 MB
Obs1,921
Magnificationother · 3.575 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse brain
GSM8396165
mouse brain glioma 51 MB 2,725 obs bronze H&E
TechnologyVisium
Organismmouse
Tissuebrain
Conditionglioma
Size51 MB
Obs2,725
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse brain
GSM8396164
mouse brain glioma 44 MB 2,383 obs bronze H&E
TechnologyVisium
Organismmouse
Tissuebrain
Conditionglioma
Size44 MB
Obs2,383
bronze H&E Open in Vitessce

Cite this collection

No linked publication found — please cite the data source.