Collections / Spatial transcriptome analysis for placental tissue of preeclampsia

Spatial transcriptome analysis for placental tissue of preeclampsia

Preeclampsia (PE) is a major pregnancy complication leading to maternal and neonatal mortality. To investigate the spatial gene expression profile of preeclampsia, we performed the Visium FFPE spatial transcriptome analysis.

Datasets2
Size~351 MB
AssayVisium
Samplehuman · placenta
KindComparison
PMID:41604492 ↗
Python · lamindb
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse266604")
coll.ordered_artifacts.df()                 # the 2 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Open in Vitessce
Visium
Human placenta
GSM8252340
human placenta preeclampsia 261 MB 12,410 obs bronze H&E
TechnologyVisium
Organismhuman
Tissueplacenta
Conditionpreeclampsia
Size261 MB
Obs12,410
Magnificationother · 7.639 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Human placenta
GSM8252339
human placenta 90 MB 12,267 obs bronze H&E
TechnologyVisium
Organismhuman
Tissueplacenta
Size90 MB
Obs12,267
Magnificationother · 7.469 µm/px
bronze H&E Open in Vitessce

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