Collections / Analysis of Spatial Transcriptomics for Unveiling the novel molecular characteristics of Recurrent and Non-Recurrent High-Grade Serous Ovarian Cancer

Analysis of Spatial Transcriptomics for Unveiling the novel molecular characteristics of Recurrent and Non-Recurrent High-Grade Serous Ovarian Cancer

Our study utilized spatial transcriptomics (ST) to interpret the tumor microenvironment to examine spatial characteristics across different sites in eight patients with HGSOC divided into recurrent (R, n = 5) and non-recurrent (NR, n = 3) groups based on a 60-month recurrence criterion. This study identified diagnostic and therapeutic targets for HGSOC, marking a step towards personalized medicine.

Datasets8
Size~466 MB
AssayVisium
Samplehuman · ovary
KindComparison
PMID:39135097 ↗
Download the whole collection
Python · lamindb 
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse263920")
coll.ordered_artifacts.df()                 # the 8 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Member datasets · 8
Visium
Human ovary
GSM8207504
human ovary ovarian serous adenocarcinoma 80 MB 4,577 obs silver H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size80 MB
Obs4,577
silver H&E
Open in Vitessce
Visium
Human ovary
GSM8207502
human ovary ovarian serous adenocarcinoma 58 MB 3,623 obs silver H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size58 MB
Obs3,623
silver H&E Open in Vitessce
Open in Vitessce
Visium
Human ovary
GSM8207499
human ovary ovarian serous adenocarcinoma 45 MB 3,509 obs silver H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size45 MB
Obs3,509
silver H&E Open in Vitessce
Open in Vitessce
Visium
Human ovary
GSM8207506
human ovary ovarian serous adenocarcinoma 70 MB 4,523 obs silver H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size70 MB
Obs4,523
silver H&E Open in Vitessce
Open in Vitessce
Visium
Human ovary
GSM8207501
human ovary ovarian serous adenocarcinoma 36 MB 2,644 obs silver H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size36 MB
Obs2,644
silver H&E Open in Vitessce
Open in Vitessce
Visium
Human ovary
GSM8207500
human ovary ovarian serous adenocarcinoma 61 MB 4,274 obs silver H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size61 MB
Obs4,274
silver H&E Open in Vitessce
Open in Vitessce
Visium
Human ovary
GSM8207505
human ovary ovarian serous adenocarcinoma 54 MB 3,103 obs silver H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size54 MB
Obs3,103
silver H&E Open in Vitessce
Open in Vitessce
Visium
Human ovary
GSM8207503
human ovary ovarian serous adenocarcinoma 62 MB 4,038 obs silver H&E
TechnologyVisium
Organismhuman
Tissueovary
Conditionovarian serous adenocarcinoma
Size62 MB
Obs4,038
silver H&E Open in Vitessce

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