Collections / Dynamic fibroblast-immune interactions shape recovery after brain injury [Visium]

Dynamic fibroblast-immune interactions shape recovery after brain injury [Visium]

Fibroblasts and immune cells coordinate tissue regeneration and necessary scarring after injury. In the brain, fibroblasts are border-enriched cells whose dynamic molecular states and immune interactions after injury remain unclear. We used spatial transcriptomics (10X Visium) to spatiotemporally profile CNS wound healing responses, including stromal and immune responses, after photothrombotic (PT) injury.

Datasets4
Size~151 MB
AssayVisium
Samplemouse · brain
KindTime course
PMID:40903576 ↗
Python · lamindb
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse254161")
coll.ordered_artifacts.df()                 # the 4 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Open in Vitessce
Visium
Mouse brain
GSM8035260
mouse brain 37 MB 2,170 obs bronze H&E
TechnologyVisium
Organismmouse
Tissuebrain
Size37 MB
Obs2,170
Magnificationother · 3.671 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse brain
GSM8035258
mouse brain 36 MB 2,743 obs bronze H&E
TechnologyVisium
Organismmouse
Tissuebrain
Size36 MB
Obs2,743
Magnificationother · 3.550 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse brain
GSM8035261
mouse brain 43 MB 2,502 obs bronze H&E
TechnologyVisium
Organismmouse
Tissuebrain
Size43 MB
Obs2,502
Magnificationother · 4.636 µm/px
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Mouse brain
GSM8035259
mouse brain 35 MB 1,925 obs bronze H&E
TechnologyVisium
Organismmouse
Tissuebrain
Size35 MB
Obs1,925
Magnificationother · 3.548 µm/px
bronze H&E Open in Vitessce

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