Collections / Clonal proliferation of smooth muscle cell in human atherosclerosis

Clonal proliferation of smooth muscle cell in human atherosclerosis

Two different coronary artery samples with erosion plaques were selected from female heterozygous for the deletion BGN. Hybridization of target RNA-specific probes was used to visualize the spatial distribution of mutants. After determine the leison with clonality and non-clonal SMC proliferation, spatial transcriptomics was used to identify differentially expressed transcripts within clonal and non-clonal regions.

Datasets2
Size~9.0 MB
AssayVisium
Samplehuman · coronary artery
KindOther
PMID:37881937 ↗
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Python · lamindb 
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse243179")
coll.ordered_artifacts.df()                 # the 2 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Member datasets · 2
Open in Vitessce
Visium
Human coronary artery
GSM7780297
human coronary artery atherosclerosis 3.3 MB 1,283 obs bronze H&E
TechnologyVisium
Organismhuman
Tissuecoronary artery
Conditionatherosclerosis
Size3.3 MB
Obs1,283
bronze H&E Open in Vitessce
Open in Vitessce
Visium
Human coronary artery
GSM7780296
human coronary artery atherosclerosis 5.7 MB 2,615 obs bronze H&E
TechnologyVisium
Organismhuman
Tissuecoronary artery
Conditionatherosclerosis
Size5.7 MB
Obs2,615
bronze H&E Open in Vitessce

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