Collections / Human Cortical Kidney Sections

Human Cortical Kidney Sections

Acute kidney injury (AKI) is a major health burden in the United States. Macrophages have been shown to mediate AKI in murine models. Murine kidneys contain multiple subpopulations of kidney resident macrophages (KRM) that are transcriptionally and spatially distinct. We hypothesized the human kidney contains orthologous KRM subpopulations, both transcriptionally and spatially. We utilized kidney sections from donors diagnosed with mild to moderate AKI in order to increase the translatability of murine research to clinical settings.

Datasets2
Size~48 MB
AssayVisium
Samplehuman · kidney
KindOther
www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE228169 ↗
Download the whole collection
Python · lamindb 
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse228169")
coll.ordered_artifacts.df()                 # the 2 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Member datasets · 2
Open in Vitessce
Visium
Human kidney
GSM7115963
human kidney acute kidney failure 23 MB 3,555 obs silver H&E
TechnologyVisium
Organismhuman
Tissuekidney
Conditionacute kidney failure
Size23 MB
Obs3,555
Magnificationother · 3.671 µm/px
silver H&E Open in Vitessce
Open in Vitessce
Visium
Human kidney
GSM7115964
human kidney acute kidney failure 24 MB 3,794 obs silver H&E
TechnologyVisium
Organismhuman
Tissuekidney
Conditionacute kidney failure
Size24 MB
Obs3,794
silver H&E Open in Vitessce

Cite this collection

No linked publication found — please cite the data source.