Collections / Time-series spatial transcriptomic analysis of murine small intestine (SI) undergoing irradiation induced injury-repair with and without LXR activation

Time-series spatial transcriptomic analysis of murine small intestine (SI) undergoing irradiation induced injury-repair with and without LXR activation

To unbiasedly characterize the spatial transcriptomics landscape of murine small intestine damage and repair, we performed a time-series spatial transcriptional analysis of total small intestinal tissue during the course of irradiation damage from mice receiving standard diet. Additionally, to understand the role of LXR activation during damage and repair, we also collected small intestine tissues from mice fed with GW3965 diet.

Datasets4
Size~212 MB
AssayVisium
Samplemouse · small intestine
KindComparison
PMID:39567700 ↗
Python · lamindb
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse227742")
coll.ordered_artifacts.df()                 # the 4 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Open in Vitessce
Visium
Mouse small intestine
GSM7106693
mouse small intestine 45 MB 4,190 obs silver H&E
TechnologyVisium
Organismmouse
Tissuesmall intestine
Size45 MB
Obs4,190
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse small intestine
GSM7106691
mouse small intestine 56 MB 4,585 obs silver H&E
TechnologyVisium
Organismmouse
Tissuesmall intestine
Size56 MB
Obs4,585
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse small intestine
GSM7106692
mouse small intestine 49 MB 4,881 obs silver H&E
TechnologyVisium
Organismmouse
Tissuesmall intestine
Size49 MB
Obs4,881
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse small intestine
GSM7106694
mouse small intestine 62 MB 4,859 obs silver H&E
TechnologyVisium
Organismmouse
Tissuesmall intestine
Size62 MB
Obs4,859
silver H&E Open in Vitessce

Cite this collection

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