Collections / mousemodel_Heptablastoma spatial transcriptomics

mousemodel_Heptablastoma spatial transcriptomics

Lack of relevant animal models and cell lines hampers the understanding of hepatoblastoma and identification of therapeutic targets. We report a hepatoblastoma murine model that faithfully recapitulates the pathological features of mixed fetal and embryonic hepatoblastoma, with transcriptomics resembling the high-risk gene signatures of human disease

Datasets5
Size~315 MB
AssayVisium
Samplemouse · liver
KindOther
PMID:37414763 ↗
Python · lamindb
import lamindb as ln
import spatialdata as sd

coll = ln.Collection.get(key="geo-gse195575")
coll.ordered_artifacts.df()                 # the 5 members, ordered

# download every member .zarr to the local cache:
paths = [a.cache() for a in coll.ordered_artifacts.all()]

# …or load each straight into memory as a SpatialData object:
sdatas = {a.key: sd.read_zarr(a.cache()) for a in coll.ordered_artifacts.all()}
Open in Vitessce
Visium
Mouse liver
GSM7016926
mouse liver hepatoblastoma 62 MB 4,992 obs silver H&E
TechnologyVisium
Organismmouse
Tissueliver
Conditionhepatoblastoma
Size62 MB
Obs4,992
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse liver
GSM7016921
mouse liver hepatoblastoma 73 MB 4,992 obs silver H&E
TechnologyVisium
Organismmouse
Tissueliver
Conditionhepatoblastoma
Size73 MB
Obs4,992
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse liver
GSM7016924
mouse liver hepatoblastoma 57 MB 4,992 obs silver H&E
TechnologyVisium
Organismmouse
Tissueliver
Conditionhepatoblastoma
Size57 MB
Obs4,992
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse liver
GSM7016923
mouse liver hepatoblastoma 63 MB 4,989 obs silver H&E
TechnologyVisium
Organismmouse
Tissueliver
Conditionhepatoblastoma
Size63 MB
Obs4,989
silver H&E Open in Vitessce
Open in Vitessce
Visium
Mouse liver
GSM7016922
mouse liver hepatoblastoma 60 MB 4,992 obs silver H&E
TechnologyVisium
Organismmouse
Tissueliver
Conditionhepatoblastoma
Size60 MB
Obs4,992
silver H&E Open in Vitessce

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